To improve interpretation of patient-reported outcome (PRO) data collected with the EORTC QOL measures the project develops thresholds for clinical importance. These thresholds will facilitate interpretation of QOL scores collected in daily clinical practice and of trial results.
We have established a definition of “clinical importance” based on interviews with cancer patients and health professionals and consensus in an international expert board (Project aim A and B have been completed).
Recruitment is expected to be finished in the upcoming months. Following data analysis the thresholds for clinical importance for the EORTC quality of life measures will be published.
The EORTC quality of life questionnaires are used to assess the perspective of cancer patients on their disease and its treatment. Such questionnaires allow to calculate scores that reflect the degree of a symptom or problem. Relying on interviews with cancer patients and health professionals, this project develops thresholds that help to determine what degree of a symptom or problem should be considered clinically important.
- Giesinger JM, Aaronson NK, Arraras JI, Efficace F, Groenvold M, Kieffer JM, Loth FL, Petersen MA, Ramage J, Tomaszewski KA, Young T, Holzner B; EORTC Quality of Life Group. A cross-cultural convergent parallel mixed methods study of what makes a cancer-related symptom or functional health problem clinically important. Psychooncology. 2018 Feb;27(2):548-555.